“Inactivation of Human Immunodeficiency Virus Type 1 by Ozone in Vitro” 

by J. Latino, K.H. Wells, J. Gavalchin, and B. J. Polesz.
excerpted from “BLOOD, the Journal of the American Society of Hematology”, Vol. 78, No.7, October 1, 1991:

“A device was designed to deliver a constant source of given concentration of ozone fluids containing Human Immunodeficiency

Virus Type 1 (HIV-1). Ozone was found to inactivate HIV-1 in a dose-dependent manner. Greater than 11 log inactivation was

achieved within 2 hours at a concentration of 1,200 ppm ozone. Similar concentrations of ozone had minimal effect on factor

VIII activity in both plasma and immunoaffinity-purified preparations of factor VIII treated for the same time period. The

data indicate that the antiviral effects of ozone include viral particle disruption, reverse transcriptase inactivation,

and/or a perturbation of the ability of the virus to bind to its receptor on target cells. Ozone treatment offers promise as

a means to inactivate human retroviruses in human body fluids and blood product preparations.”

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