"Inactivation of Human Immunodeficiency Virus Type 1 by Ozone in Vitro" 

by J. Latino, K.H. Wells, J. Gavalchin, and B. J. Polesz.
excerpted from "BLOOD, the Journal of the American Society of Hematology", Vol. 78, No.7, October 1, 1991:

"A device was designed to deliver a constant source of given concentration of ozone fluids containing Human Immunodeficiency

Virus Type 1 (HIV-1). Ozone was found to inactivate HIV-1 in a dose-dependent manner. Greater than 11 log inactivation was

achieved within 2 hours at a concentration of 1,200 ppm ozone. Similar concentrations of ozone had minimal effect on factor

VIII activity in both plasma and immunoaffinity-purified preparations of factor VIII treated for the same time period. The

data indicate that the antiviral effects of ozone include viral particle disruption, reverse transcriptase inactivation,

and/or a perturbation of the ability of the virus to bind to its receptor on target cells. Ozone treatment offers promise as

a means to inactivate human retroviruses in human body fluids and blood product preparations."

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Thirteen Major Effects of Ozone On The Human Body - Dr. Frank Shallenberger

1. Ozone stimulates the production of white blood cells. These cells protect the body from viruses, bacteria, fungi and

cancer. Deprived of oxygen, these cells malfunction. They fail to eliminate invaders and even turn against normal, healthy

cells (allergic reactions). Ozone significantly raises the oxygen levels in the blood for long periods after ozone

administration; as a result, allergies have a tendency to become desensitized.

2. Interferon levels are significantly increased. Interferons are globular proteins that orchestrate every aspect of the

immune system. Some interferons are produced by cells infected by viruses. These interferons warn adjacent, healthy cells of

the likelihood of infection; in turn, they are rendered nonpermissive host cells, inhibiting viral replication. Other

interferons are produced in the muscles, connective tissue and by white blood cells. Levels of gamma interferon can be

elevated 400-900% by ozone. This interferon is involved in the control of phagocytic cells that engulf and kill pathogens and

abnormal cells. Synthetic interferons are FDA approved for the treatment of Chronic Hepatitis B and C, Genital Warts (caused

by Papilloma virus, Hairy-cell Leukemia, Kaposi's Sarcoma, Relapsing-Remitting Multiple Sclerosis and Chronic Granulomatous

Disease. Interferons are currently in clinical trials for Throat Warts (caused by Papilloma virus), HIV infection, Chronic

Myelogenous Leukemia Leukemia, Non-Hodgkins Lymphoma, Colon tumors, Kidney tumors, Bladder Cancer, Malignant Melanoma, Basal

Cell Carcinoma and Leishmaniasis. While levels induced by ozone remain safe, interferon levels that are FDA-approved (and in

clinical trials) are extremely toxic.

3. Ozone stimulates the production of Tumor Necrosis Factor. TNF is produced by the body when a tumor is growing. The greater

the mass of the tumor the more tumor necrosis factor is produced (up to a point). When a tumor has turned metastatic, cancer

cells are breaking off and being carried away by the blood and lymph, allowing the tumor to take up residence elsewhere in

the body. These lone cancer cells have little chance of growing due to the TNF produced to inhibit the original tumor. When

the tumor is removed surgically TNF levels drop dramatically and new tumors emerge from seemingly healthy tissue.

4. Ozone stimulates the secretion of IL-2. Interleukin-2 is one of the cornerstones of the immune system, secreted by

T-helpers. In a process known as autostimulation, the IL-2 then binds to a receptor on the T-helper and causes it to produce

more IL-2. Its main duty is to induce lymphocytes to differentiate and proliferate, yielding more T-helpers, T-suppressors,

cytotoxic T's, T-delayeds and T-memory cells.

5. Ozone kills most bacteria at low concentrations. The metabolism of most bacteria is on average one-seventeenth as

efficient as our own. Because of this, most cannot afford to produce disposable anti-oxidant enzymes such as catalase. Very

few types of bacteria can live in an environment composed of more than two percent ozone.

6. Ozone is effective against all types of fungi. This includes systemic Candida albicans, athlete's foot, molds, mildews,

yeasts and even mushrooms.

7. Ozone is the best virucide. As discussed above, ozone goes after the viral particles directly. The part of the virus most

sensitive to oxidation is the "reproductive structure". This is how the virons enter the cell. With this structure

inactivated, the virus is essentially "dead". Cells already infected have a natural weakness to ozone. Due to the metabolic

burden of the infection the cells can no longer produce the protective enzymes necessary to deal with the ozone and repair

the cell.

8. Ozone is antineoplastic. This means that ozone inhibits the growth of new tissue because rapidly dividing cells shift

their priorities away from producing the enzymes needed to protect themselves from the ozone. Cancer cells are rapidly

dividing cells and are thus inhibited by ozone.

9. Ozone oxidizes arterial plaque. It breaks down the plaque involved in both Arteriosclerosis and Atherosclerosis. This

means ozone has a tendency to clear blockages of small and even large vessels. This allows for better tissue oxygenation in

deficient organs.

10. Ozone increases the flexibility and elasticity of red blood cells. When one views a red blood cell under a microscope, it

looks like a disc. In the capillaries, where they pick-up (lungs) and release (tissue) oxygen, these discs stretch out into

the shape of an oval or umbrella. This aids their passage through the tiny capillaries and makes the exchange of gas more

efficient. The increase in flexibility of the RBC's allows oxygen levels to stay elevated for days, or even weeks after

treatment with ozone.

11. Ozone accelerates the Citric Acid Cycle. Also known as the Kreb's Cycle or TCA Cycle, this is a very important step in

the glycolysis of carbohydrate for energy. This takes place in the mitochondria of the cell. Most of the energy stored in

glucose (sugar) is converted in this pathway.

12. Ozone makes the anti-oxidant enzyme system more efficient. Cells respond to the beneficial oxidative stress by increasing

their production of the protective enzymes.

13. Ozone breaks down petrochemicals. These chemicals have a potential to place a great burden on the immune system. They

also worsen and even cause allergies and are detrimental to your long-term health.

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What's the story on Ozone in the Air? - Brenda Myers 

Ozone is perhaps the most misunderstood component of the air we breathe. Ozone is nature's purifier, and no amount of

propaganda from vested interests can change that fact. Ozone is the best air cleaner available for ridding a home of mould,

mildew, bacteria, odors and aerosol pollutants.

Indoor air pollution is a growing concern for many people. Untreated, recirculated air containing hydrocarbons, tobacco

smoke, kerosene fumes, carbon monoxide, formaldehyde, dust and mites is increasingly being blamed for health problems. Even

small amounts of these pollutants will cause adverse effects if the duration of exposure is long enough.

In a series of studies published in 1976, the Soviet Department of Health established many important facts concerning the use

of ozone in closed indoor environments. They found that after five months of continuous daily exposure to ozone levels of

.015 ppb, symptoms of sick building syndrome vanished. Also, immune potential was increased, blood pressure readings

improved, oxygen content in blood rose, and stress levels dropped. The overall effect was very close to that experienced by

taking a brisk two hour walk in a park daily.

Additional Soviet studies by the Institute of Child and Adolescent Hygiene showed that injection of ozone into school HVAC

systems had similarly positive results. In controlled tests, 69% of the students exposed to a level of .015 ppb ozone

decreased the amount of time required to complete tasks requiring high levels of concentration. In addition, researchers

observed favorable changes in the functions of external respiration, increases in mental reserve capacity and overall

increases in the children's state of health.

It is important to keep your home free of hazardous aerosol pollutants. Small amounts of ozone are extremely effective at

purifying and revitalizing indoor air. Filtration in combination with ozonation is an even more efficacious route to take,

albeit more expensive, and requiring more periodic maintenance.

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THE FREE RADICAL THEORY - Dr. Deepak Chopra 

In the 1950s, Dr. Denham Harman of the University of Nebraska theorized that free radicals are an important cause of aging at

the cellular level. This is believed to happen through a process called cross-linkage, a chemical reaction that locks up the

outer atomic shells of collagen. The cause of cross-linkage is thought to be the tendency of free radicals to bind

indiscriminately with many vital molecules in the body, including DNA.

Cross-linkage is only one example of the damage free radicals can inflict. They can supposedly split up molecules, garble

information in cells, clog cell membranes, promote cancerous mutations, and impair the function of the mitochondria (the

energy factories inside each cell). Free radicals will attack almost any molecule; the extent of the damage they do is so

wide that the free radical theory of aging has grown in popularity with each passing decade.

Paradoxically, free radicals are necessary to life. A free radical is really a temporary stopping-point leading from one

stable molecule to another. The normal life-span of such unstable particles is thousandths of a second; millions of these

fleeting molecules are emitted in every cell as it burns sugar with life-giving oxygen.

Why does the body produce free radicals? They are the natural product of any chemical reaction and they fit into the body's

overall balance. In the immune system, white blood cells use free radicals in hydrogen peroxide to destroy invading bacteria

and viruses. In that role, the free radical's tendency to latch onto anything in sight saves your life daily.

To protect itself from any damage, every cell produces enzymes to neutralize free radicals. These free radical scavengers

include superoxide dismutase, glutathione peroxidase and catalase. In recent times, people have been urged to take large

amounts of free radical scavengers in order to minimize cell damage. However, the eminent Japanese medical investigator Dr.

Yukie Niwa, himself a staunch proponent of the free radical theory, has demonstrated in the laboratory that dosing a culture

of cells with these products does little to decrease free radical production. It would be still less effective for a person

to swallow these scavengers, as most would be nullified by digestive juices long before they got to the cells they were meant

to protect.

The whole life extension enterprise misses the point. The damage caused by free radicals is secondary, not causal. In its

normal state, the body controls free radicals as a matter of course. Your body is not blindly fighting for its life against

"bad" chemicals; such a notion is far too simplistic. If you could view a cell as it produces its myriad free radicals and

myriad scavengers at the same time, you would see the two floating around in the same environment, not like loose cannons,

but closely monitored and controlled by the cell. Both are kept in balance and used as the cell requires, in serene harmony.

It has not been shown that older people have necessarily higher levels of free radicals in their cells or lower levels of

scavengers. Free radical damage is only one type of imbalance that can occur at the cellular level. If the body's generative

powers are at optimum, disorder and chaos do not attack a cell.

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CONTEMPORARY OZONE APPLICATIONS - Dr. Kurt Donsbach

In order to appreciate ozone one must first understand fully the critical role that oxygen plays. Oxygen is by far the most

important necessity of human life. It performs hundreds of tasks in the body, but the two most important are energy

production and detoxification.

The production of energy in the body is accomplished by the combination of glucose with oxygen, producing ATP. The body makes

an amount of ATP equivalent to your body weight every 24 hours. If you make 10% less ATP than normal, you will feel tired and

sluggish. If ATP production falls too far, you will deteriorate rapidly, and die. Energy is life and the production of energy

in the body depends upon oxygen.

The second important function of oxygen is to combine with metabolic waste products to allow their elimination from the body.

This process is called the oxidation-reduction cycle. When insufficient oxygen is available, the detoxification process slows

down, wastes pile up, circulation becomes sluggish, oxygen is prevented from reaching the cells and disease results. Thus, we

can see that oxygen is essential to these two vital phases of life.

Since oxygen is the most critical requirement for life, the ingestion of substances that increase the level of oxygen in the

body are the most beneficial to optimum health. The best sources of oxygen are ozone, hydrogen peroxide and magnesium

peroxide.

Ozone treatment is safe because healthy cells are surrounded by an enzyme coating, which ozone does not penetrate. Bacteria

and viruses have no such coatings and are oxidized on contact by ozone. Ozone also promotes the production of glutathione

peroxidase, catalase, reductase and super-oxide dismutase which are the anti-oxidant enzymes in the cell and therefore

cellular immunity is enhanced.

Ozone also has a measurable benefit on the uptake and utilization of oxygen through improved glycolysis in red blood cells,

reduction of clumping of red blood cells and the stimulation of mitochondrial respiration. This improved cellular respiration

is invaluable in preventing cancer.

Cancer begins when a normal cell cannot get enough oxygen. If the level of oxygen available falls below 40%, in order to

survive, the cell will begin to ferment sugar instead of burn it. This process is irreversible, and results in an energy

output only 1/6 as great as oxidation. The cell then lacks the energy to manufacture a proper enzyme coating around itself.

The governor on cell replication is switched off, and the cell can begin to make copies of itself wildly. This ungoverned

cell replication is called cancer.

When ozone is introduced into the area, it immediately attacks the unhealthy cells because they lack a proper enzyme coating.

Healthy cells are untouched. If sufficient ozone is administered over time, the tumor will be dissolved.

The applications of medical ozone include performance enhancement, increased longevity, accelerated wound healing, dentistry,

heart disease, all infections, treatment of all gastroenteric diseases, immune stimulation, treatment of all cancers, and

gerontology. Ozone also combines well with intravenous chelation therapy which is used to treat arterial disease or heavy

metal toxicity. Chelation therapy works quite slowly through a number of infusions, and adding ozone can speed this process

up.

Ozone provides an immediate oxygen boost to heart tissue which can noticeably reduce the incidence of angina. It also

improves brain function, because the brain uses over 15% of all the oxygen in the body.

The naso-pharyngeal area is often the site of chronic minor infections which become acute in cycles. Chronic sinusitis is

probably one of the most common maladies of today. The introduction of ozone into the ear canals can be of great benefit in

reducing such chronic infections.

Another method of getting ozone into the body is with the use of a closed, one-person steam sauna. Since the pores will be

open in the moist heat, ozone can be easily absorbed in large amounts through the skin very safely.

The use of ozone for medical therapy is well-established and is being vigorously pursued by many enlightened clinicians. It

has an excellent safety record and no toxic side effects have been observed in millions of treatments over nearly 100 years.

As technology develops, new techniques will undoubtedly emerge that will enlarge the scope of the effective use of this

healing modality.

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Ozone Applications - Brad Hunter, P.Eng.

Ozone is triatomic oxygen. As a gas it is blue; both liquid ozone (-112 C) and solid ozone (-193 C) are a deep blue color. It

is this blue ozone in the atmosphere that causes the sky to be blue. At altitudes from 25-30 km ozone is created by a portion

of the sun's ultraviolet spectrum. It exists as a gas in concentrations of 10-20 parts per million (ppm). In these

concentrations, ozone is a powerful absorber of a narrow portion of the sun's ultraviolet radiation.

At ground level, ozone exists in a greatly diluted state and is always present in minute quantities (.001-.003 ppm) which we

breathe in. It does not become an irritant until levels above .1 ppm are exceeded for over eight hours. Below those levels

there have never been any permanent detrimental effects from inhaling it.

Ozone is created naturally by crashing surf, whitewater rapids, and lightning storms.

Recently, ozone has come to public attention as an alleged pollutant in smog. In order to measure hydrocarbon air pollution,

an index is required. High levels of hydrocarbons have a corresponding ozone level (since the ozone is created from, and

attracted to, the pollutants), so by measuring the ozone, scientists can measure indirectly how bad the pollution is. What is

not mentioned is that the ozone molecule lasts for a maximum of 20 minutes, and usually much less, as it tirelessly eats up

the hydrocarbon pollution by oxidizing it. The harmful constituents of smog: carbon monoxide, benzene, chlorides, sulphur

dioxide, and nitric oxide are swiftly oxidized on contact by ozone, thus cleaning the air.

Ozone has long been internationally recognized as the most powerful oxidant next to hydroxyl, which is a mixture of ozone

with hydrogen peroxide. Ozone is used in over 30 different industries as an industrial oxidizer and sterilant. Existing

applications include: synthetic fibers, chemicals, jet lubricants, air scrubbing for clean rooms, treatment of industrial

wastes, potable water treatment, bottling plants, sewage treatment, aquaculture, aquarium sanitation, food preservation,

sterilization of containers, deodorization, pulpwood bleaching, metal extraction, etc.

Ozone's most well known use is in water treatment as a primary stage disinfectant because of its bactericidal and virucidal

efficacy. Both the EPA and the FDA acknowledge ozone's ability to oxidize 99.9992% of all waterborne pathogens.

Ozone has been used for human health since 1870, and is presently employed in 24 countries. Its widest use is in Germany,

where over 7000 doctors have treated more than 12,000,000 people since WW II. In the United States, the FDA has not allowed

testing of ozone, and, since 1933, has actively persecuted physicians who use it. Nevertheless, more and more doctors are

turning to ozone therapy as a crucial tool for the treatment of serious diseases. In fourteen states, Alaska, Washington,

Colorado, Oklahoma, New Mexico, Nevada, North Carolina, New York, Texas, Georgia, Ohio, Minnesota, Florida and California,

physicians are now able to employ any therapeutic technique, including ozone, without fear of persecution. In Dr. H.E.

Sartori's recent book, the multiple uses of ozone for human health, dentistry, animal health and industrial uses are well

covered. Tragically, Dr. Sartori himself was recently jailed for administering ozone in Virginia.

There are three technologies utilized for the generation of ozone:
# Ultraviolet light
# Corona discharge
# Cold plasma.

Ultraviolet light in the 180-190 nanometer wavelength generates ozone from ambient air without producing nitric oxide

compounds. But UV cannot generate the concentrations necessary for medical or industrial applications, even with oxygen feed.

Typically, UV systems produce only 1-3 ug/ml, sufficient only for air purification and cleaning of water in small quantities.

UV lamps degrade quickly and are expensive to replace.

Corona discharge generates high concentrations of ozone, up to 150 ug/ml, required for industrial applications. If it is

properly engineered and used in conjunction with an air dryer, it may be used with ambient air. It is the most cost effective

way to produce large quantities of ozone, but reliability is always a problem. An improved variation is called dual

dielectric, used for medical purposes, but long term reliability is again problematic, due to shorting from the cathode to

the metal anode.

Cold plasma is a technique invented by Nikola Tesla whereby noble gases are enclosed in a glass vacuum tube and high voltage

is applied. This is where the future lies for medical applications, because a clean flow of 50 ug/ml is obtainable from this

technology with very long-term reliability. The original Tesla generators of the 1920s still operate perfectly today.

Different uses of ozone require different concentrations to obtain desired results. UV generated ozone is adequate for small

pools, but larger pools, water parks and municipal water treatment require corona discharge to generate large quantities of

ozone. It is important to deal with people who are familiar with the specific applications of ozone in order that systems are

designed to address the problem of each individual installation.

Water engineers use a value called CT (concentration x time) to measure the amount of work done by an oxidant. It is

important to consider the time factor when using ozone, especially when there is a large amount of undesirable material to be

oxidized. Insufficient time of contact or too low a concentration will produce incomplete results.

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FREE RADICALS, OZONE AND ANTIOXIDANTS - Dr. Horst Kief 

As with everything on our planet, both oxygen and antioxidants have two sides, the positive and the negative. On one side,

free radicals will age us quicker; on the other side, without them we have no immune system. It is not well known that oxygen

is bound to our hemoglobin as a superoxide anion, so the oxygen in our breathing process is already there as a radical.

It is the same with antioxidants. Antioxidants are often prescribed to be taken along with the use of ozone. These are not

simply opposites that cancel each other out, but rather, a thoughtful optimization, since most antioxidants have very

specific tasks. Vitamin E is active at the cell membrane. Vitamin C is itself a radical that can speed the electron flow

through oxidation. If ozone is taken for a long time at a high dose, it is wise to take Vitamin A as a preventive measure to

prevent the problems of Vitamin A deficiency.

In summary, both effects have their function and their place in a symbiotic relationship.

OZONE AND ITS USE IN MEDICAL THERAPY - Dr. Robert Willner 

The different modes of action of ozone on a living organism are now well understood. The production of peroxides is

responsible for the remarkable bactericidal and fungicidal effects of ozone. The virus inactivation is enhanced by a peroxide

intolerance of weakened infected cells. Normal cells are protected from the effects of ozone by enzymes in the cell wall -

glutathione peroxidase, catalase and superoxide dismutase. Ozone stimulates the production of these enzymes, thus enhancing

the cell wall resistance to invasion.

In addition, ozone has been shown to have a measurable benefit on the uptake and utilization of oxygen with improved

glycolysis in red blood cells through the abolition of harmful red blood cell stacking (rouleaux). In addition, ozone

stimulates and activates mitochondrial respiration and metabolic pathways.

All mammalian tissues depend for their survival and health on an adequate oxygen uptake and therefore ozone would benefit

every person through optimizing tissue oxygenation. Thus ozone has a preventative as well as remedial role. The application

for prevention would include increasing longevity, enhancing performance, rejuvenating seniors, optimizing the healing of

wounds, and stimulating immunity.

Ozone's therapeutic remedial uses are extensive and growing daily. All bacterial, viral and fungal infections are eliminated

by ozone therapy. Heart disease, angina, arteriosclerosis, gangrene, senile dementia, ulcers, varicose veins, arthritis,

ankylosing spondylitis, diabetes, all forms of cancer, Parkinson's disease, inflammatory bowel disease, immune deficiency,

allergies and asthma are just a few of the conditions that are regularly treated with ozone.

Ozone combines extremely well with intravenous chelation therapy which is used to treat arterial disease and heavy metal

toxicity.

The therapeutic use of ozone has an excellent safety record and no toxic effects have been observed from clinical use. The

use of ozone as a healing adjunct is well established and is being vigorously pursued by many scientists and clinicians. The

benefits are predictable and without side effects. As technology advances, undoubtedly new techniques will enlarge the scope

of the effective use of this versatile modality.

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OZONE AND THE FUTURE OF PREVENTION - Byrun F. Tylor 

Ozone has recently become the treatment of choice by progressive doctors for serious diseases, such as cancer, diabetes, and

immune deficiencies. With a series of ozone injections, or ozone steam sauna treatments, coupled with exercise, dietary

changes, emotional counseling, various cleanses and herbal remedies, great strides have been made in dealing with many of the

most serious diseases.

Unfortunately, less attention has been paid to the use of ozone for prevention of diseases. However, the increasing financial

instability of our Medicare system may soon force the issue. As Canada drifts closer to the American style system of

user-pay, Canadians will increasingly consider preventive health measures in order to lower their own personal costs.

This is where ozone can help in the home. Taken on a regular basis in drinking water, in the ear, by insufflation, or in an

ozone steam sauna, ozone safely cleanses bodily fluids of stored toxins, bacteria, yeasts, fungi and viruses. Cleaning the

body in this way and keeping it clean over the years will go a long way towards optimizing health and preventing both

degenerative diseases and also communicable diseases. This will end the need for vaccination and inoculation, with their

appalling tendency to cause the diseases they were meant to prevent. There will also be no need for antibiotics and

tranquilizers, with their damaging side effects and mixed results.

There will be no reason to fear epidemics of meningitis, fleas-eating strep bacteria, toxoplasmosis, hamburger disease, Ebola

virus, Hanta virus, etc., that are trumpeted by the media. And, of course, no reason to pay any attention to the endless

cancer scare stories.

In the future, it is our hope that ozone will routinely treat and prevent all of these diseases. When the public becomes

aware of its power, then prevention will become the watchword, and the general health of Canadians will improve while costs

plummet. This is the future of prevention.

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CALCIUM, VITAMIN D and CANCER - Dr. K.W. Donsbach, DC, ND, PhD

Calcium is primarily deposited in the hard tissue structures of the body, namely the bones and the teeth, which contain over 1,000,000 mg of calcium. A considerable amount of calcium is also found in the lymphatic tissue, between the cells. Only 200mg of the body's total calcium is found in the blood stream. But this minute amount is so important for life that elaborate measures are taken to make sure that it is always present, for calcium is used to fire the muscles, including the heart.

Calcium requires vitamin D in order to be absorbed through the wall of the intestine. When the level of calcium in the blood drops, extra Vitamin D is mobilized in the kidneys and rushed to the abdominal wall to pull more calcium into the blood stream. If there is insufficient Vitamin D available to ensure calcium can be obtained by absorption, the parathyroid gland kicks in with the hormone (PTH) message to the bones and teeth to give up calcium for the blood.

The overwhelming majority of non-bone calcium is in the extra-cellular fluid at a ratio of 10,000:1 (with the 1 being inside the cell). This ratio is so critical that even small calcium level variations in the cell will produce gross changes, such as abnormal movement of the cell, extra-excitability of the cell, and worst of all, abnormal cell division.  An inadequate intake of calcium, which could result from dietary deficiency of either calcium or Vitamin D, will cause the parathyroids to signal the bones to give up calcium. Now comes what is referred to as the "calcium paradox". The extra amounts of calcium which flood out of the bone when stimulated by PTH often overshoot the amount needed by the blood. An excess of calcium in the blood is just as serious a threat to life as too little. Therefore, when the normal calcium level is reached, any excess is quickly deposited in soft tissues such as the lining of arteries (arteriosclerosis); brain tissue (premature senility); and into joints (arthritis).

But it is the disturbance of the delicate balance of calcium inside and outside the cell that really produces problems. When even a tiny amount of excess calcium enters a cell and changes the 10,000:1 outside:inside ratio, the cell's "imbalance of calcium" signal erupts, which can create a life-threatening disease, called cancer.

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OZONE THERAPY - Fritz Schellander

Ozone therapy is one of the most powerful and versatile therapies known today. Extensive medical research on ozone therapy has been done primarily in Europe. Through its mechanism of action, ozone has beneficial effects on every part of the body.

The effects include:

1. Inactivation of bacteria, viruses and fungi: Ozone disrupts the integrity of the bacterial cell envelope through peroxidation of the phospholipids and lipoproteins. In fungi, ozone inhibits cell growth at certain stages. With viruses, the ozone oxidizes the viral capsid and disrupts the reproductive cycle by interrupting the virus-to-cell contact with peroxidation. Cells previously infected by viruses are more susceptible to destruction by the peroxide produced through ozonolysis, because they have weak enzyme coatings.

2. Enhancement of circulation: In circulatory disease, a clumping of red blood cells hinders blood flow and decreases oxygen absorption due to reduced surface area. There is a decrease in red blood cell flexibility which prevents them traveling down the tiniest capillaries, and blood viscosity increases. With ozone therapy, clumping is reduced or eliminated and flexibility is restored, along with oxygen carrying ability. Oxygenation of the tissues increases as the arterial partial pressure increases, and viscosity decreases. Ozone also oxidizes the plaque in arteries allowing the removal of the breakdown products, unclogging vessels.

3. Stimulation of oxygen metabolism: Ozone causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2.3-diphosphoglycerate which shifts the oxyhemoglobin disassociation curve to the right. This leads to an increase in the amount of oxygen released to the surrounding tissues. There is a stimulation of the production of the enzymes which act as free radical scavengers and cell wall protectors: glutathione peroxidase, catalase and superoxide dismutase.

Ozone activates the Krebs cycle by enhancing oxidative decarboxylation of pyruvate, stimulating production of ATP.

4. Dissolution of malignant tumors: Malignant cells have an increased rate of glycolysis which leads to the production of more lactic acid. With ozone therapy, there is a significant decrease in lactate production, showing that the metabolism is being inhibited. Tumor cells have a peroxide intolerance due to insufficient glutathione peroxidase and catalase. Ozone is thus able to oxidize the outer lipid layer of malignant cells and destroy them through cell lysis.

5. Activation of the immune system: Ozone stimulates the production of gamma interferon and interleukin-2 in the body. From this there is a cascade of subsequent immunological reactions.

6. Formation of peroxides: Ozone reacts with the unsaturated fatty acids of the lipid layer in cellular membranes, forming hydro peroxides. Lipid peroxidation products include peroxyl radicals, vital for killer cell action.

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FREE RADICAL PATHOLOGY - excerpted from "Chelation Therapy"

From the beginning of time, man has searched for a way to regain youth and retard aging. Countless cures, remedies and potions have come along, each promising to be the real thing. Medical doctors have searched for an answer as to why people age and why the degenerative diseases take such a toll. The free radical theory attempts to explain these problems.  It is believed that man's maximum lifespan depends primarily on genetics.

Whether or not the lifespan is fulfilled is believed to be dependent on the damage that free radicals cause to DNA, leading to degenerative diseases such as diabetes, arthritis, atherosclerosis, Parkinson's and Alzheimer's.

Humans are composed of 75 trillion highly specialized cells. These cells vary a great deal in structure and in the functions they perform. Free radicals are produced in our cells due to normal respiration and assimilation of sugar. Atoms normally contain an even number of paired electrons. During chemical reactions, electrons become unpaired momentarily, allowing the reaction to occur. If for some reason, an electron becomes separated, it will cause an imbalance and become a free radical.

This unbalanced free radical can damage cells that do not have sufficient enzyme protection. These enzymes are catalase, reductase, glutathione peroxidase and superoxide dismutase. In healthy cells, these enzymes prevent cell damage from free radicals. When cellular health declines due to toxic buildup, and enzyme production declines, free radicals are able to cause damage. It is believed that degenerative disease is caused by this type of action.

We can limit the damage caused by free radicals by arming ourselves with free radical scavengers are Vitamin E, Vitamin C,

Vitamin A and beta carotene, and selenium.

During the First World War, the application of ozone to war wounds served primarily as a disinfectant. In 1934, the dentist E.A. Fische and the surgeon Erwin Payr found that ozone saturated water was a great bactericide and began using it. This usage slowed temporarily because the ozone would quickly destroy the rubber tubing it flowed through. The arrival of Teflon and silicone tubing overcame this problem.

Today the largest commercial use of ozone is in the purification of water. Both the FDA and EPA certify ozone as destroying 99.9992% of all pathogenic germs, while simultaneously oxidizing 99.9992% of all water-borne pollutants.

Through the action of the flashes of lightning, and the photochemical reaction of the UV light of the sun on atmospheric oxygen, nature produces ozone for the purpose of purifying the air, and to destroy all organic decay upon which disease germs and bacteria thrive. Like oxygen, ozone is a healthful gas. It has, however, much greater oxidizing, antiseptic and germicidal power and for this reason is being used with great success for the relief of various diseases. For years physicians around the world have used ozone for bringing palliative and curative results to many, many individuals. Special stress should be laid on the fact that ozone is a NATURAL remedy.

Through the respiratory system, sufficient oxygen is carried to the cells of the body to combine with the carbon and hydrogen in sugar, creating ATP and heat, and the oxidized waste products CO2 and water. Heat is continually being generated through this union of carbon, hydrogen and oxygen, maintaining normal body temperature (98.6 F). A sufficiency of oxygen for the blood means better blood, better circulation, better assimilation, better equilibrium of body temperature, better vasomotor activity, better digestion, better elimination of waste products, less chance of autointoxication or toxemia, and less chance of infection and disease. The organs perform their functions properly, wastes are eliminated and the system is in a condition to resist the toxic influences of microbes, environment and mankind's excesses.

When, however, an insufficient amount of oxygen is received by the cell, carbon monoxide (CO) is formed, which is NOT readily eliminated, and through its poisonous influences, trouble begins. Carbon monoxide is a DE-oxidizer. It acts as an irritant to the organs, and the body temperature is reduced below normal. The system becomes acidic and is rendered incapable of resisting the influences of bacteria, viruses and environmental toxins, and disease is the result. So prevalent is subnormal temperature among people who are called 'run down' that nine out of ten of them will show a subnormal temperature by actual thermometer test. There have been several reasons given for subnormal temperatures in recent years: they range from 'thyroid insufficiency' to 'hypothalamus disorders'. These explanations are correct, but only to a degree. The CAUSE of the problem is inadequate oxidation. The thyroid, hypothalamus, or endocrine organs (given as the cause) are hindered in their normal metabolic function and the sub-normal temperature is the result. The clinical thermometer is the best means of determining the existence of under-oxygenation and should be used routinely. The temperature of one who is under-oxygenated will be found to run from a fraction to several degrees below normal. The way to counteract this situation is to restore the oxidative process.

The symptoms or conditions that rise from a subnormal temperature are not necessarily in proportion to the degree of subnormal temperature. A person showing a fractional part of one degree of subnormal temperature may present as severe problems or conditions of disease as one who is several degrees below normal.

It has been suggested that a subnormal temperature may be a normal condition with some people. This deduction can be disproven by placing anyone with a subnormal temperature under active influence of ozone and the temperature can be made to rise back to normal. Almost all forms of nervous, functional, respiratory and blood disorders can be successfully corrected by oxidation restoration. The effects are perfectly natural, the nerves being left calm and toned with a feeling of buoyancy and exhilaration. It stimulates the vasomotor system through the nerve centers, which fact is clearly shown in the increased redness of the skin, a feeling of warmth in the whole body, and waste products being more freely eliminated.

In 1928, Dr. Otto Warburg discovered the cause of cancer by demonstrating that when the level of oxygen available to the cell drops below 40% of normal, the cell, in order to survive, begins to ferment its sugar anerobically. The waste products, lactic acid and carbon monoxide are acidic. T-cells secrete enzyme growth factors in response to the acidity around the cell, and the cell is stimulated to make copies of itself wildly. This growth of cancerous cells, based on fermentation, can be initiated only in the relative absence of oxygen.

Oncologists since that time have been attempting to stop the fermentation process through drugs, radiation and surgery, which in some cases, has been temporarily successful. Although the National Cancer Institute verified Warburg's theories in 1952, they have done very little follow up work, although huge amounts of money have been spent pursuing different drug treatments. The reluctance of US authorities to investigate ozone's therapeutic abilities since then has condemned many millions of American citizens (over 500,000 per year) to a painful, needless death.

The Sixth World Ozone Conference held in Washington D.C. during May, 1982, produced many astounding papers on the medical uses of ozone. They ran the full gamut of topics from cancer to herpes to rheumatoid arthritis, written by the world's recognized specialists in their fields. These papers concluded that:

1. Ozone removes unwanted bacteria and viruses from the blood, the same way it does with water.

2. The possibility of becoming infected with hepatitis, HIV, syphilis or other infectious diseases through blood transfusion could be eliminated by the use of ozone.

3. Ozone is highly effective in peripheral vascular disease.

4. Ozone is effective in cardiovascular and cerebrovascular disease, arteriosclerosis and hyper-cholesterolemia, and promptly restores circulation, relieves angina pain and improves brain function.

5. With ozone, cancerous tumors, lymphomas and leukemia may be eliminated without the use of surgery, radiation or chemotherapy.

6. Ozone is highly effective for all forms of rheumatoid and arthritis collagen diseases.

7. Ozone is very effective for allergies of all types.

8. Ozone improves multiple sclerosis, and other neurological diseases, senility, as well as in Parkinson's disease.

9. External use of ozone is very effective in treating burns, acne, leg ulcers, open cuts and wounds, eczema, fungus and other skin disorders.

10. Rectal insufflation with ozone is effective for proctitis, colitis, prostatitis and fissure; vaginal insufflation is effective for candidiasis and other yeast infections, trichomoniasis and other forms of vaginitis; bladder insufflation is effective for cystitis and bladder fistulas, as well as cancer.

11. AIDS, herpes, hepatitis, mononucleosis, and cirrhosis of the liver have been successfully treated with ozone.

12. The application of ozone is virtually painless, has no adverse side effects and is extremely cost-effective for both physicians and patients.

13. As of 2000, eighteen countries allow the use of ozone therapy, and thirteen US states. In a study in Germany, with over 12 million treatments, there were only four deaths reported, with only 40 persons having side effects.

Most people are puzzled as to why something with this potential is not being used widely in the United States. In order to understand this, one has to examine how medicine has evolved over the past 100 years on two continents, Europe and America.

In the late 1800's, the way medicine was practiced in both areas was very similar, though quite diverse. Doctors on both continents were taught many different techniques of healing including herbal medicine, potions, manipulations, diets, purges, colonics, ozone therapy, as well as drugs and surgery. These physicians practiced holistic medicine in its original form. The divergence began in the United States with the discovery of the sulfa drugs, insulin and penicillin in the 1930's. In close conjunction with the rise in power of the drug companies was the increasing power of the AMA and the closer policing of all medical therapies by the FDA, along with the development of the health insurance system. Today's American doctors get practically no training in therapies other than drugs or surgery and are discouraged from practicing any alternative therapies. On the other hand the European system nurtured diversity, in which pharmaceutical development, as well as alternative treatments, were encouraged. This is how ozone, as a medical treatment, was allowed to develop in Europe, but was suppressed in the United States after 1933.

Ozone itself is not patentable, although ozone generators are. Thus, there is little money to be made from its research and development as a treatment, since it cannot be completely protected. Money is what makes things happen in the United States, thus ozone hasn't happened. However, with the development of the AIDS crisis over the last two decades, many physicians in this country have been prompted to study the work done by clinicians in Germany and attempt to duplicate their results. The FDA actively persecutes doctors who use this efficacious therapy, even though drug treatments have been worse than useless. FDA persecution has also driven out all American manufacturers of medical ozone generators.